Yes, but it depends really on what you want to bind where.
In my case, I have no capslock and I have ESC, TAB, shift, ctlr (on the outermost column) and alt, super, lower, space (on the bottom row/thumb. Obviously with qmk (or similar) you can change what you want, but I assumed it was pretty standard layout (in fact, I changed very little from stock keymaps in qmk).