Guide is maybe not the right word lol, it just exactly what I click to set up the majority of my games
I’m not 100% sure, but from my understanding yes the regisrty in the “prefix” folder would be changed. You can manually edit the wine prefix registry with regedit www.winehq.org/docs/…/using-regedit and Lutris supports this, just click the arrow that brings up the winetricks option and its under Wine Registry