Honestly with the exception of trying out Nvidia drivers until they worked nicely (took 3 tries the first time back when I was on Ubuntu because it had nouveau as default and I miss read the first time) everything worked fine with wine or proton (or was just Linux compatible in the first place) and often I had better performance too.
Now on endeavouros I do more tinkering but I still don’t have any problems except on my Wayland machine which experiences stutter in a few games but I’m guessing that will be fixed later this year with the new drivers and Wayland protocol changes.