I switched to a TKL (tenkeyless) to reduce the distance between my hands when my right hand is on the mouse, and it feels so much better.
I got a programmable keyboard, so I remapped the keys around where my right hand rests to be the numpad keys when I hold the capslock key. That way I can still have the convenience of the numpad without having an actual dedicated numpad, although I’m still getting used to using it this way.