When the protagonist’s character, personality, and story is significant, then that’s fine. If I’m playing a game like that I’m not playing a generic character that could be either and therefore should absolutely be a choice.
I’m fine playing a game like the Witcher, Red Dead 2, etc, cause those are the stories of that guy.
Where I won’t play is games that give you a generic protagonist with little to no personality but restrict you to male only, or even I suppose female only, although this is incredibly rare and I haven’t run across it myself.