As for Windows plugins with no native Linux version, there are ways to use VSTs over Wine. Check out Yabridge project. There’s no guarantee that 100% of plugins will work, but many do pretty well. It requires some additional setup, but once it’s done, you don’t have to think about it much, just call yabridgectl when you add new plugins to sync them (it creates stub library that is seen as Linux native, but it wraps Windows plugin using Wine)
Reaper is perfectly fine choice if you’re already familiar with it, but here are some other you may want to look at:
FOSS Options:
Ardour - it’s pretty old, UX is not perfectly intuitive, basically GIMP of the audio world, but it can do everything you’d expect a professional DAW to do, while being incredibly lightweight. It’s straightforward to install on any Linux system.
Zrhythm - it’s a new DAW that didn’t have a stable release yet, but it’s on 1.0 RC1 so I guess it’s pretty close. It has some promising user interface and feature set, also easy to get installed, but might not be super solid just yet.
Commercial options:
Bitwig Studio - probably the best audio workstation for Linux, but also the most expensive.
Waveform Tracktion - I personally had mixed experience with it. On one hand the UX and flow is quite good (not as flexible as ardour, way more opinionated, but still fully functional and easier to use), but I had bad time dealing with a large project as the editor becomes extremely sluggish as your project grows.