I have heard very good things about it, but I can’t talk for myself, as I haven’t played it. My only recommendation is to stay away from the console versions of the game, as I tried it on Xbox One and it was unplayable (heard the same about the PS4 port, too). Maybe it’s better on next gen, but I wouldn’t risk it.
Two things worth mentioning:
The remake only has one character, the Haruspex. If you want to play as the Bachelor or the Changeling, you’ll need to grab the original game.
There are difficulty settings in the remake. I would leave them as default, as I think the difficulty of the game, and the conflicting decisions you’ll need to undertake because of it, is an integral part of the experience. That being said, if you really like the game and want to see it through, you can tweak the difficulty a bit, and accessibility is always a plus in my book.
Again, this is just hearsay as I haven’t played it, but from what I’ve gathered, Pathologic 2 is more a retelling than a faithful remake. Same setting and same ending, but a different road, so to speak. You could play either one and then move on to the other if you like it.