Most of their games at this point are pretty different than Bethesda rpgs. Pentiment, Grounded, Pillars of Eternity, Tyranny, Pathfinders, Stick of Truth etc. They’ve actually gone on to make some pretty unique titles, while Bethesda has milked the rpg cow for pretty much their entire existence.
Avowed was originally pitched as Obsidian's take on Skyrim (www.rockpapershotgun.com)