Pcie x16 slot? (you could look up in the board manual how fast it is - number of lanes and pcie version. But basically the standard is downwards compatible - newer cards work in older slots, but slower. )
Dimensions: does it fit in the case? Is the cooling (outtake of the case) sufficient?
Power supply ready? Check if the psu (power supply unit) delivers enough power to supply the new gpu. Check if there are the right plugs/ cables to feed the gpu - some require one 75w-connector, some even two.