Daaamn ut03 wasn’t easy to get last time i checked. Generally would say i prefer 04, but 03 was my first contact so it holds a special nostalgia to me. Will have to look again!
Sundered is a cool 2D metroidvania / action rogue lite blend.
Absolutely gorgeous artstyle, unique concept…
Loop Hero is another rogue lite, that has a bit more of a management feel to it. The hero traverses the loop (the level) automatically - you just get to change their equipment and the environment. It’s a cool balancing act between making a tough level with synergetic enemy types/tiles and making sure your hero survives.
Hollow Knight - if you like metroidvanias you probably know that one. It’s incredibly popular! amazing game.
Dead Cells - same basically :) 50% off on steam right now!
Edit: Seems like you’re looking for retro/emulation stuff mostly? I might be misunderstanding your comments.
These recommendation all have Switch and PC versions. No clue how well they would run on yuzu
“Best” and “most important” are also two very different things. Like tetris, pong, doom and some other trail blazers might not be the kind of long-term engaging many people would think of when coming up with best games. But their impact and long term effects on the tech, the market or design of games is impossible to ignore.