It was something I was aware of and against when I was on Reddit ever since I first heard of them.
And they don’t even make cheating impossible. Cheats don’t need to be running on the OS that is running the game. It could be running in a VM. I believe many VM implementations will let the guest OS know that they are running on a VM, but that isn’t mandatory. Other hardware in the system can have full access to the memory space and do reads/writes without the OS knowing (though caches complicate this). Some cheats just act as a display and mouse, processing the display as it passes through the device to the monitor, and modifying the mouse input to correct aim based on what it sees. If it spoofs a monitor and mouse, nothing in the kernel will necessarily see any difference.